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Hiroshi Yuitaa, Isaac F. López-Moyadoa,b, Hyeongmin Jeongc, Arthur Xiuyuan Cheng, James Scott-Browned, Jungeun An, Toshinori Nakayamag, Atsushi Onodera, Myunggon Ko, and Anjana Rao. (2023) Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-toeuchromatin switch. PNAS February 1, 2023 DOI:10.1073/pnas.2214824120

Jungeun An and Myunggon Ko (2023) Epigenetic Modification of Cytosines in Hematopoietic Differentiation and Malignant Transformation. MDPI Published: 15 January 2023 DOI:10.3390/ijms24021727


Tan Y, You C, Park J, Kim HS, Guo S, Schärer OD, Wang Y (2022) Transcriptional Perturbations of 2,6-diaminopurine and 2-aminopurine. ACS Chem Biol, published on June 15, 2022, as DOI:10/1021/acschembio.2c00369

Kim M, Kim HS, D’Souza A, Gallagher K, Jeong E, Topolska-Wos A, Ogorodnik Le Meur K, Tsai CL, Tsai MS, Kee M, Tainer JA, Yeo JE, Chazin WJ, Schärer OD (2022), Two Interaction Surfaces Between XPA and RPA Organize the Preincision Complex in Nucleotide Excision Repair, bioRvix, DOI:10.1101/2022.03.01.482439

Dong Gil Jang, Keun Yeong Kwon, Yeong Cheon Kweon, Byung-gyu Kim, Kyungjae Myung, Hyun-Shik Lee, Chan Young Park, Taejoon Kwon, Tae Joo Park (2022) GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base. ELIFE DOI:10.7554/eLife.81016

Charlotte Blessing, Katja Apelt, Diana van den Heuvel, Claudia Gonzalez-Leal, Magdalena B. Rother, Melanie van der Woude, Roman Gonzalez-Prieto, Adi Yifrach, Avital Parnas, Rashmi G. Shah, Tia Tyrsett Kuo, Daphne E. C. Boer, Jin Cai, Angela Kragten, Hyun-Suk Kim, Orlando D. Scharer, Alfred C. O. Vertegaal, Girish M. Shah, Sheera Adar, Hannes Lans, Haico van Attikum, Andreas G. Ladurner, Martijn S. Luijsterburg (2022) XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair. NATURE COMMUNICATIONS DOI:10.1038/s41467-022-31820-4

Mihyun Kim, Hyun Suk Kim, Areetha D’Souza, Kaitlyn Gallagher, Eunwoo Jeong, Agnieszka Topolska-Woś, Kateryna Ogorodnik Le Meur, Chi-Lin Tsai, Miaw-Sheue Tsai, Minyong Kee, John A. Tainer, Jung-Eun Yeo, Walter J. Chazin, Orlando D. Scharer (2022) Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair. Proceedings of the National Academy of Sciences of the United States of America DOI:10.1073/pnas.2207408119

Min Kyung Ju, Joo Rak Lee, Yeonsong Choi, Seon Young Park, Hee Jung Sul, Hee Jin Chung, Soyeong An, Semin Lee, Eunyoung Jung, Bohyun Kim, Bo Youn Choi, Bum Jun Kim, Hyeong Su Kim, Hyun Lim, Ho Suk Kang, Jae Seung Soh, Kyungjae Myung, Kab Choong Kim, Ji Woong Cho, Jinwon Seo, Tae Moon Kim, Ja Yil Lee, Yonghwan Kim, Hongtae Kim, Dae Young Zang (2022) PWWP2B promotes DNA end resection and homologous recombination. EMBO Reports DOI:10.15252/embr.202153492

Yue Z, Wu F, Guo F, Park J, Wang J, Liyun Z, Lao D, Li W, Schärer OD, Lei X (2022) Polycarcin V induces DNA damage response and enables the profiling of DNA-binding proteins Nat Sci Rev, DOI:10/1093/nr/nwac046

Eunjin Ryu, Na Young Ha, Woojae Jung, Juyeong Yoo, Kyungjae Myung, Sukhyun Kang (2022) Distinct Motifs in ATAD5 C-Terminal Domain Modulate PCNA Unloading Process. CELLS DOI:10.3390/cells11111832

S. Byun, C.H. Lee, H. Jeong, H. Kim, H.M. Kwon, S. Park, Kyung Jae Myung, J. An, Myunggon Ko (2022) Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression. Proceedings of the National Academy of Sciences of the United States of America DOI:10.1073/pnas.2205626119

Kibum Kim, Hee Chan Yoo, Byung Gyu Kim, Sulhee Kim, Yulseung Sung, Ina Yoon, Ya Chun Yu, Seung Joon Park, Jong Hyun Kim, Kyungjae Myung, Kwang Yeon Hwang, Sunghoon Kim, Jung Min Han (2022) O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine. NATURE COMMUNICATIONS DOI:10.1038/s41467-022-30696-8

van Toorn M, Turkyilmaz Y, Han S, Zhou D, Kim HS, Salas-Armenteros I, Kim M, Akita M, Wienholz F, Raams A, Ryu EJ, Kang S, Theil AF, Bezstarosti K, Tresini M, Giglia-Mari G, Demmers JA, Schärer OD, Choi JH, Vermeulen W, Marteijn JA (2022) Active DNA damage eviction by HLTF stimulates nucleotide excision repair. Mol Cell, 82, 1343-1358.

Aloisi CMN, Escher NA, Kim HS, Geisen S, Fontana G, Yeo JE, Schärer OD*, Sturla SJ* (2022) A combination of direct reversion and nucleotide excision repair counters the mutagenic effects of DNA carboxymethylation. DNA Repair 110, 103262


Taejoon Kwon, Jae Sun Ra, Soyoung Lee, In-Joon Baek, Keon Woo Khim, Eun A. Lee, Eun Kyung Song, Daniyar Otarbayev, Woojae Jung, Yong Hwan Park, Minwoo Wie, Juyoung Bae, Himchan Cheng, Jun Hong Park, Namwoo Kim, Yuri Seo, Seongmin Yun, Ha Eun Kim, Hyo Eun Moon, Sun Ha Paek, Tae Joo Park, Young Un Park, Hwanseok Rhee, Jang Hyun Choi, Seung Woo Cho, Kyungjae Myung (2022) Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9. Proceedings of the National Academy of Sciences of the United States of America DOI:10.1073/pnas.2103532119

Joon Ho Rhlee, Saikat Maiti, Jeong Woo Lee, Ho Seung Lee, Ismoili Ahror Bakhtiyorzoda, Soochan Lee, Jaehyun Park, Seok Ju Kang, Yung Sam Kim, Jeong Kon Seo, Kyungjae Myung, Wonyoung Choe, Sung You Hong (2022) Synthesis of alpha,beta-unsaturated ketones through nickel-catalysed aldehyde-free hydroacylation of alkynes. Communications Chemistry DOI:10.1038/s42004-022-00633-3

Gartner A, Engebrecht J. (2022) DNA repair, recombination, and damage signaling. GENETICS, Vol. 220, No. 2. Link to paper

Jung-Min Oh, Kyungjae Myung (2022) Crosstalk between different DNA repair pathways for DNA double strand break repairs. Mutation Research - Genetic Toxicology and Environmental Mutagenesis DOI:10.1016/j.mrgentox.2021.503438

Youngran Kim, Junhyeon Park, So Young Joo, Byung-Gyu Kim, Aera Jo, Hyunsook Lee, Yunje Cho (2022) Structure of the Human TELO2-TTI1-TTI2 Complex. Journal of Molecular Biology DOI:10.1016/j.jmb.2021.167370

Seon-Gyeong LeeNamwoo Kim, In Bae Park, Jun Hong Park, Kyungjae Myung (2022) Tissue-specific DNA damage response in Mouse Whole-body irradiation. Molecular and Cellular Toxicology DOI:10.1007/s13273-021-00195-w


Apelt K, Lans H, Schärer OD, Luijsterburg MS (2021) Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes. Cell Mol Life Sci, 78, 7925-7942.


von Werdt A, Brandt L, Schärer OD, Rubin MA (2021) PARP Inhibition in Prostate Cancer with Homologous Recombination Repair Alterations. JCO Precis Oncol, 5, 1639-1649.


Cheun YK, Groehler AS 4th, Schärer OD (2021) New Synthetic Analogs of Nitrogen Mustard DNA Interstrand Crosslinks and Their Use to study Bypass DNA polymerases. Chem Res Tox 34, 1790-1799.

Tsao N, Schärer OD*, Mosammaparast N* (2021) The complexity and regulation of the repair of alkylation damage to nucleic acids. Crit Rev Biochem Mol Biol, doi:10.1080/10409238.2020.1869173


Apelt K, White SM, Kim HS, Yeo JE, Kragten A, Wondergem AP, Rooimans MA, Gonzalez-Prieto R, Wiegant WW, Lunke S, Flanagan D, Pantaleo S, Quinlan C, Hardikar W, van Attikum H, Vertegaal CO, Wilson BT, Wolthuis RMF, Schärer OD, Luijsterburg MS (2021) ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients. J Exp Med 218 , e20200622


Kim T, Gartner A. (2021) Bub1 kinase in the regulation of mitosis. Animal Cells and Systems, 25 (1): 1-10. Link to paper


Meier B, Volkova NV, Hong Y, Bertolini S, González-Huici V, Petrova T, et al. (2021) Protection of the C. elegans germ cell genome depends on diverse DNA repair pathways during normal proliferation. PloS one, 16 (4): e0250291. Link to paper


Hong Y, Zhang H, Gartner A. (2021) The Last Chance Saloon. Frontiers in Cell and Developmental Biology, 9: 1249. Link to paper


Meier B, Volkova NV, Wang B, González-Huici V, Bertolini S, Campbell PJ, et al. (2021) C. elegans genome-wide analysis reveals DNA repair pathways that act cooperatively to preserve genome integrity upon ionizing radiation. PloS one, 16 (10): e0258269. Link to paper

Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes

Shin, Unbeom; Nakhro, Khriezhanuo; Oh, Chang-Kyu; Carrington, Blake; Song, HeaIn; Varshney, Gaurav K.; Kim, Yeongjae; Song, Hyemin; Jeon, Sangeun; Robbins, Gabrielle; Kim, Sangin; Yoon, Suhyeon; Choi, Yong Jun; Kim, Yoo Jung; Burgess, Shawn; Kang, Sukhyun; Sood, Raman; Lee, Yoonsung; Myung, Kyungjae [DNA Repair   107(2021) ]

NSMF promotes the replication stress-induced DNA damage response for genome maintenance

Ju, Min Kyung; Shin, Kyeong Jin; Lee, Joo Rak; Khim, Keon Woo; Eun A. Lee; Jae Sun Ra; Byung-Gyu Kim; Jo, Han-Seul; Yoon, Jong Hyuk; Tae Moon Kim; Kyungjae Myung; Choi, Jang Hyun; Hongtae Kim; Chae, Young Chan [Nucleic acids research   49(10), 5605-5622(2021) ]


AML poor prognosis factor, TPD52, is associated with the maintenance of haematopoietic stem cells through regulation of cell proliferation

Kang, JW; Kim, Y; Yoonsung Lee; Kyungjae Myung; Kim, YH; Chang‐Kyu Oh [JOURNAL OF CELLULAR BIOCHEMISTRY   122(3-4), 403-412(2021) ]


FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity

Chang-Kyu Oh; Ko, Yeji; Park, Jeong Jun; Heo, Hye Jin; Kang, Junho; Kwon, Eun Jung; Kang, Ji Wan; Yoonsung Lee; Kyungjae Myung; Kang, Jin Mo; Ko, Dai Sik; Kim, Yun Hak [BIOSCIENCE REPORTS   41(1), 1-11(2021) ]


TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution

Hyun Je Kang; Na Young Cheon; Hyun Park; Gyu Won Jeong; Byeong Jin Ye; Eun Jin Yoo; Jun Ho Lee; Jin-Hoe Hur; Eun-A Lee; Hongtae Kim; Kyoo-young Lee; Soo Youn Choi; Whaseon Lee-Kwon; Kyungjae Myung; Ja Yil Lee[CGI]; Hyug Moo Kwon [Nucleic Acids Research   49(1), 269-284(2021) ]


Neuropeptide Y: a potential theranostic biomarker for diabetic peripheral neuropathy in patients with type-2 diabetes

Cho, Noo Ree; Yu, Yeuni; Oh, Chang-Kyu; Ko, Dai Sik; Myung, Kyungjae; Lee, Yoonsung; Na, Hee Sam; Kim, Yun Hak [Therapeutic Advances in Chronic Disease   12(2021) ]


Tsutakawa SE, Tsai CL, Yan C, Bralić A, Chazin WJ, Hamdan SM, Schärer OD, Ivanov I, Tainer JA (2020) Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair. DNA Repair, 96, 102972.


Rageul J, Park J, Zeng PP, Lee EA, Yang JY, Hwang SY, Lo N, Westheimer A, Schärer OD, Yeo JE*, Kim HJ* (2020) SDE integrates into the TIMELESS-TIPIN Complex to Protect Stalled Replication Forks. Nature Communications, 11, 5495 

Hwang T, Reh S, Dunbayev Y, Zhong Y, Takata Y, Shen J, McBride KM, Murnane JP, Bhak J, Lee S, Wood RD, Takata KI (2020) Defining the mutation signatures of DNA polymerase θ in cancer genomes, NAR Cancer, 2, zcaa017

Bezalel-Buch R, Cheun YK, Roy U, Schärer OD, Burgers P (2020) Bypass of DNA interstrand crosslinks by a Rev1-DNA Polymerase Z complex. Nucleic Acids Res, 48, 8461-8473

Son K, Schärer OD (2020) Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation Cell 180, 1039-1041


Jeong E, Lee SK, Kim HS, Yang J, Shin J, Kim J, Schärer OD, Kim Y, Yeo JE, Kim HM, Cho Y (2020) Structural basis of the Fanconi anemia-associated mutations within the FANCA and FANCG complex Nucleic Acids Res, 48, 3328-3342

Topolska-Woś AM, Sugitani N, Cordoba JJ, Le Meur KV, Le Meur RA, Kim HS, Yeo JE, Rosenberg D, Hammel M, Schärer OD, Chazin WJ (2020) Interaction with RPA orients XPA in NER complexes. Nucleic Acids Res, 48, 2173-2188

Raghunandan M, Yeo JE, Walter R, Saito K, Harvey AJ, Ittershagen S, Lee EA, Yan J, Hoatlin ME, Bielinsky AK, Hendrickson EA, Schärer OD, Sobeck A (2020) Functional crosstalk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery. Hum Mol Genet, 29, 1083-1095.


Volkova, N. V., Meier, B., González-Huici, V., Bertolini, S., Gonzalez, S., Vöhringer, H., Abascal, F., Martincorena, I., Campbell, P. J., and Gartner, A., Gerstung M. (2020) Mutational signatures are jointly shaped by DNA damage and repair, Nature Communications 11, 1-15. Link to paper *Co-correspondence

Song, J., Freeman, A. D., Knebel, A., Gartner, A., and Lilley, D. M. (2020) Human ANKLE1 is a nuclease specific for branched DNA, Journal of molecular biology 432, 5825-5834. Link to paper *Co-correspondence

Meier, B., Volkova, N. V., Gerstung, M., and Gartner, A. (2020) Analysis of mutational signatures in C. elegans: Implications for cancer genome analysis, DNA repair 95, 102957. Link to paper

Lee, S. g., Kim, N., Kim, S. m., Park, I. B., Kim, H., Kim, S., Kim, B. g., Hwang, J. M., Baek, I. J., and Gartner, A., Park, J.H., Myung, K. (2020) Ewing sarcoma protein promotes dissociation of poly (ADP‐ribose) polymerase 1 from chromatin, EMBO reports 21, e48676. Link to paper

The HLTF–PARP1 interaction in the progression and stability of damaged replication forks caused by methyl methanesulfonate

Shiu, Jia-Lin; Wu, Cheng-Kuei; Chang, Song-Bin; Sun, Yan-Jhih; Chen, Yen-Ju; Lai, Chien-Chen; Chiu, Wen-Tai; Chang, Wen-Tsan; Kyungjae Myung; Su, Wen-Pin; Liaw, Hungjiun [Oncogenesis   9(12)(2020) ]


Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h

Sophia G. Espanola; Hyemin Song; Eunjin Ryu; Aditya Saxena; Eun-Sun Kim; Jennifer E. Manegold; Chanond A. Nasamran; Debashis Sahoo; Chang-Kyu Oh; Cara Bickers; Unbeom Shin; Stephanie Grainger; Yong Hwan Park; Lauren Pandolfo; Mi-Sun Kang; Sukhyun Kang; Kyungjae Myung; Kimberly L. Cooper; Deborah Yelon; David Traver; Yoonsung Lee [NATURE CELL BIOLOGY   22, 1411-1422(2020) ]


O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease

Lee, Byeong Eun; Kim, Hye Yun; Kim, Hyun-Jin; Jeong, Hyeongsun; Byung-Gyu Kim; Lee, Ha-Eun; Lee, Jieun; Kim, Han Byeol; Lee, Seung Eun; Yang, Yong Ryoul; Yi, Eugene C.; Hanover, John A.; Kyungjae Myung; Suh, Pann-Ghill; Kwon, Taejoon; Kim, Jae-Ick [BRAIN   143(12), 3699-3716(2020) ]


Eukaryotic clamp loaders and unloaders in the maintenance of genome stability

Kyoo-young Lee; Su Hyung Park [Experimental and Molecular Medicine   52(12), 1948-1958(2020) ]


Ewing sarcoma protein promotes dissociation of poly(ADP-ribose) polymerase 1 from chromatin

Seon-gyeong Lee; Namwoo Kim; Su-min Kim; In Bae Park; Hyejin Kim; Shinseog Kim; Byung-Gyu Kim; Jung Me Hwang; In-Joon Baek; Anton Gartner; Jun Hong Park; Kyungjae Myung [EMBO REPORTS   21(11), e48676-(2020) ]


LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function



Background-suppressed live visualization of genomic loci with an improved CRISPR system based on a split fluorophore

Narendra Chaudhary; Si-Hyeong Nho; Hayoon Cho; Narangerel Gantumur; Jae Sun Ra; Kyungjae Myung; Hajin Kim [GENOME RESEARCH   30(9), 1306-1316(2020) ]


FAM213A is linked to prognostic significance in acute myeloid leukemia through regulation of oxidative stress and myelopoiesis

Chang-Kyu Oh; Ha M.; Han M.-E.; Heo H.J.; Kyungjae Myung; Yoonsung Lee; Oh S.-O.; Kim Y.H. [HEMATOLOGICAL ONCOLOGY   38(3), 381-389(2020) ]


ATAD5 suppresses centrosome over-duplication by regulating UAF1 and ID1

Seong-jung Kim; Minwoo Wie; Su Hyung Park; Tae Moon Kim; Jun Hong Park; Shinseog Kim; Kyungjae Myung; Kyoo-young Lee [CELL CYCLE   19(15), 1952-1968(2020) ]


ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork

Sangin Kim; Nalae Kang; Su Hyung Park; James Wells; Taejoo Hwang; Eunjin Ryu; Byung Gyu Kim; Sunyoung Hwang; Seong-jung Kim; Sukhyun Kang; Semin Lee; Peter Stirling; Kyungjae Myung; Kyoo-young Lee [NUCLEIC ACIDS RESEARCH   48(13), 7218-7238(2020) ]


Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis

Choi, SS; Lee, SK; Kim, JK; Park, HK; Lee, E; Jang, J; Lee, YH; Khim, KW; Hyun, JM; Eom, HJ; Lee, S; Kang, BH; Chae, YC; Kyungjae Myung; Myung, SJ; Park, CY; Choi, JH [EXPERIMENTAL AND MOLECULAR MEDICINE   52(6), 940-950(2020) ]


Role of kif2c, a gene related to ALL relapse, in embryonic hematopoiesis in Zebrafish

Chang-Kyu Oh; Kang J.W.; Yoonsung Lee; Kyungjae Myung; Ha M.; Kang J.; Kwon E.J.; Kim Y.; Oh S.-O.; Heo H.J.; Kim S.; Kim Y.H. [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   21(9), 3127-(2020) ]


Simple Method to Characterize the Ciliary Proteome of Multiciliated Cells

Sim H.J.;Yun S.;Kim H.E.;Kwon K.Y.;Kim G.-H.;Yun S.;Kim B.G.;Myung K.;Park T.J.;Kwon T. [JOURNAL OF PROTEOME RESEARCH   19(1), 391-400(2020) ]



Srinivasan G, Williamson EA, Kong K, Jaiswal AS, Huang G, Kim HS, Schärer O, Zhao W, Burma S, Sung P, Hromas R (2019) MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers. Proc Natl Acad Sci USA, 35, 17438-17443

Cheon NY, Kim HS, Yeo JE, Schärer OD, Lee JY (2019) Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B. Nucleic Acids Res, 47, 8337-8437

Liu X, Jiang Y, Takata K, Nowak B, Liu C, Wood RD, Hittelman WN, Plunkett W (2019) CNDAC-induced DNA double strand breaks cause aberrant mitosis prior to cell death. Mol Cancer Ther., 18, 2283-2295


Bailly, A. P., Perrin, A., Serrano-Macia, M., Maghames, C., Leidecker, O., Trauchessec, H., Martinez-Chantar, M., Gartner, A., and Xirodimas, D. P. (2019) The balance between mono-and NEDD8-chains controlled by NEDP1 upon DNA damage is a regulatory module of the HSP70 ATPase activity, Cell reports 29, 212-224. e218. Link to paper


ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress

Su Hyung Park;Nalae Kang;Song E.;Wie M.;Eun A. Lee;Sunyoung Hwang;Lee D.;Jae Sun Ra;In Bae Park;Jieun Park;Sukhyun Kang;Jun Hong Park;Hohng S.;Kyoo-young Lee;Kyungjae Myung [NATURE COMMUNICATIONS   10(1), 5718-(2019) ]


PCNA Unloading Is Negatively Regulated by BET Proteins

Mi-Sun Kang;Jinwoo Kim;Eunjin Ryu;Na Young Ha;Sunyoung Hwang;Byung-Gyu Kim;Jae Sun Ra;Yeong Jae Kim;Jung Me Hwang;Kyungjae Myung;Sukhyun Kang [CELL REPORTS   29(13), 4632-4645.e5(2019) ]


TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1

Kang H.J.;Park H.;Yoo E.J.;Lee J.H.;Choi S.Y.;Lee-Kwon W.;Kyoo-young Lee;Hur J.-H.;Seo J.K.;Jae Sun Ra;Eun-A. Lee;Kyungjae Myung;Kwon H.M. [iScience   19, 177-190(2019) ]


CTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaks

Soon Young Hwang;Mi Ae Kang;Chul Joon Baik;Yejin Lee;Ngo Thanh Hang;Byung-Gyu Kim;Joo Seok Han;Jae-Hoon Jeong;Daechan Park;Kyung Jae Myung;Jong-Soo Lee [NUCLEIC ACIDS RESEARCH   47(17), 9160-9179(2019) ]


Heterozygous variants in MYBPC1 are associated with an expanded neuromuscular phenotype beyond arthrogryposis

Shashi V.;Geist J.;Lee Y.;Yoo Y.;Shin U.;Schoch K.;Sullivan J.;Stong N.;Smith E.;Jasien J.;Kranz P.;Yoonsung Lee;Shin Y.B.;Wright N.T.;Choi M.;Kontrogianni-Konstantopoulos A. [HUMAN MUTATION   40(8), 1115-1126(2019) ]


The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination

Park, Jumi;Lee, Song-yi;Jeong, Hanbin;Kang, Myeong-gyun;van Haute, Lindsey L.;Minczuk, Michal;Seo, Jeong-kon;Jun, Youngsoo;Kyungjae Myung;Rhee, Hyun-woo;Changwook Lee [NUCLEIC ACIDS RESEARCH   47(13), 7078-7093(2019) ]


Label-free optical projection tomography for quantitative three-dimensional anatomy of mouse embryo

Ban S.;Cho N.H.;Min E.;Bae J.K.;Ahn Y.;Shin S.;Park S.-A.;Yoonsung Lee;Jung W. [JOURNAL OF BIOPHOTONICS   12(7), 201800481-(2019) ]


Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes

Mi-Sun Kang;Eunjin Ryu;Seung-Won Lee;Jieun Park;Na Young Ha;Jae Sun Ra;Yeong Jae Kim;Jinwoo Kim;Mohamed Abdel-Rahman;Su Hyung Park;Kyoo-young Lee;Hajin Kim;Sukhyun Kang;Kyungjae Myung [NATURE COMMUNICATIONS   10, 2420-(2019) ]


Chemoselective Trifluoroethylation Reactions of Quinazolinones and Identification of Photostability

Saikat Maiti;Jaeshin Kim;Jae-Heon Park;Dongsik Nam;Jae Bin Lee;Ye-Jin Kim;Jung-Min Kee;Jeong Kon Seo;Kyung Jae Myung;Jan-Uwe Rohde;Wonyoung Choe;Oh-Hoon Kwon;Sung You Hong [JOURNAL OF ORGANIC CHEMISTRY   84(11), 6737-6751(2019) ]


Evaluation of the prognostic significances of γ-secretase genes in pancreatic cancer

Jeon Y.H.;Ha M.;Kim S.W.;Kim M.J.;Lee C.-S.;CHANG‑KYU OH;Han M.-E.;Oh S.-O.;Kim Y.H. [ONCOLOGY LETTERS   17(5), 4614-4620(2019) ]


Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia

Chang H.R.;Cho S.Y.;Lee J.H.;Lee E.;Seo J.;Lee H.R.;Cavalcanti D.P.;Mäkitie O.;Valta H.;Girisha K.M.;Lee C.;Neethukrishna K.;Bhavani G.S.;Shukla A.;Nampoothiri S.;Phadke S.R.;Park M.J.;Ikegawa S.;Wang Z.;Higgs M.R.;Stewart G.S.;Jung E.;Lee M.-S.;Park J.H.;Eun A. Lee;Hongtae Kim;Kyungjae Myung;Jeon W.;Lee K.;Kim D.;Kim O.-H.;Choi M.;Lee H.-W.;Kim Y.;Cho T.-J. [AMERICAN JOURNAL OF HUMAN GENETICS   104(3), 439-453(2019) ]


Tonicity-responsive enhancer binding protein promotes hepatocellular carcinogenesis, recurrence, and metastasis

Jun Ho Lee;Jae Hee Suh;Soo Youn Choi;Hyun Je Kang;Hwan Hee Lee;Byeong Jin Ye ;Gap Ryol Lee;Seok Won Jung;Chang Jae Kim;Whaseon Lee-Kwon;Jiyoung Park;Kyungjae Myung;Neung Hwa Park ;Hyug Moo Kwon [GUT   29(2), 492-504(2019) ]



Mu H, Geacintov NE, Broyde S, Yeo JE, Schärer OD (2018) Molecular Basis for Damage Recognition and Verification by XPC-RAD23B and TFIIH in Nucleotide Excision Repair . DNA Repair, 71, 33-42

Jin HS, Roy U, Lee G, Schärer OD, Cho Y (2018) Structural Mechanism of DNA Interstrand Cross-Link Unhooking by the Bacterial FAN1 Nuclease. J Biol Chem 293, 6482-6406.


A novel mechanism of regulation of SHPRH by circular RNA, circ-SHPRH in glioblastoma

Shinseog Kim, Soomin Kim, Yuri Seo, Kyungjae Myung [Non-coding RNA Investigation   doi: 10.21037/ncri.2018.06.03(2018) ]


Sumoylation of the histone demethylase KDM4A is required for binding to tumor suppressor p53 in HCT116 colon cancer cell lines

Seung Eun Yu, Su Hyung Park & Yeun Kyu Jang [Animal Cells and Systems   22(1), 22-28(2018) ]


Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells

Jina Lee, Min Seong Kim, Su Hyung Park, Yeun Kyu Jang [Scientific Reports   8(2018) ]


Xenopus: An alternative model system for identifying muco-active agents

Hyo Jung Sim, Sang-Hyun Kim, Kyung-Jae Myung, Taejoon Kwon, Hyun-Shik Lee, Tae Joo Park [PLOS one, In Press.   (2018) ]


Tonicity-responsive enhancer binding protein promotes hepatocellular carcinogenesis, recurrence, and metastasis

Jun Ho Lee, Jae Hee Suh, Soo Youn Choi, Hyun Je Kang, Hwan Hee Lee, Byeong Jin Ye, Gap Ryol Lee, Seok Won Jung, Chang Jae Kim, Whaseon Lee, Jiyoung Park, Kyungjae Myung, Neung Hwa Park, Hyug Moo Kwon [Gut   doi: 10.1136/gutjnl-2017-315348.(2018) ]


Ring Finger Protein 126 suppresses ionizing radiation-induced 53BP1 foci formation

Nam Soo Lee, Hae Ryung Chang, Soomi Kim, Jae Hun Ji, Joorak Lee, Hyun Ji Lee, Yoojeong Seo, Misun Kang, Joo Seok Han, Kyungjae Myung, Yonghwang Kim, and Hongtae Kim [Journal of Biological Chemistry   293(2), 588-598(2018) ]




Cheun Y, Schärer OD (2017) Studying DNA Repair Pathways Using Site-Specifically Modified Oligonucleotides (Invited Newsletter Review), Glen Rep 29.1, 6-9.

Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, Beese LS, Schärer OD, Yan H, Gottesman ME, Takahashi TS, Gautier J (2017) Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. Cell Rep 5, 1375-1385

Thompson E, Yeo JE; Lee EA; Kan Y, Raghunandan M, Wiek C, Hanenberg H, Schärer, OD, Hendrickson EA, Sobeck A (2017) FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response. Nucleic Acids Res, 45, 11837-11857

Schärer, O.D. (2017) ERCC1-XPF endonuclease – positioned to cut (News and Views Article). EMBO J, 36, 1993-1995

Castaño A, Roy U, Schärer OD (2017) Preparation of Stable Nitrogen Mustard DNA Inter Strand Crosslink Analogs for Biochemical and Cell Biological Studies. Methods Enzymol, 591, 415-431

Beagan K, Armstrong RL, Witsell A, Roy U, Renedo N, Baker AE, Schärer OD, and McVey M (2017) Drosophila DNA Polymerase Theta Utilizes both Helicase-Like and Polymerase Domains during Microhomology-Mediated End Joining and Interstrand Crosslink Repair. PLoS Genetics, 13, e1006813

Woodrick JA, Gupta S, Camacho S, Parvathaneni S, Choudhury S, Cheema A, Bai Y, Khatakar P, Erzikan HV, Sami, F, Su Y, Schärer OD, Sharma S, Roy R (2017) A new sub-pathway of long-patch base excision repair involving 5' gap formation. EMBO J, 36, 1605-1622.

Pande P, Ji S, Mukherjee S, Schärer OD, Tretyakova NY, Basu AK (2017) Mutagenicity of a model DNA-peptide crosslink in human cells: Roles of translesion synthesis polymerases. Chem Res Tox, 30, 669-677.


Quantitative Analysis of Cell Proliferation by a Dye Dilution Assay: Application to Cell Lines and Cocultures

Soobin Chung, Seol-Hee Kim, Yuri Seo, Sook-Kyung Kim, Ji Youn Lee [Cytometry   91(7), 704-712(2017) ]


Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions.

Supriya Sinha, Fuyang Li, Diana Villarreal, Jae Hoon Shim, Suhyeon Yoon, Kyungjae Myung, Eun Yong Shim, and Sang Eun Lee [PLOS Genetics   13(4)(2017) ]


Efficient copper catalysts for C[sbnd]H bond arylation under microwave heating: Direct access to multi-substituted pivanilides

Hyun Ji Yang, Bijoy P. Mathew, Dong Gun Oh, Kyungjae Myung, Ja Hun Kwak, Sung You Hong [CATALYSIS COMMUNICATIONS   90, 83-86(2017) ]

TET family dioxygenases and DNA demethylation in stem cells and cancers.

Jungeun An, Anjana Rao and Myunggon Ko [Experimental & Molecular Medicine   49(2017) ]


Nucleosomes influence multiple steps during replication initiation

Ishara F. Azmi, Shinya Watanabe, Michael F. Maloney, Sukhyun Kang, Jason A Belsky, David M. MacAlpine, Craig L. Peterson, Stephen P. Bell [Elife   (2017) ]


Eukaryotic DNA replication: Orchestrated action of multi-subunit protein complexes

Sukhyun Kang, Mi-Sun Kang, Eunjin Ryu, Kyungjae Myung [Mutation Research   S0027-5107(17), 30056-30058(2017) ]


SET domain-containing protein 5 is required for expression of primordial germ cell specification-associated genes in murine embryonic stem cells

Yu SE, Kim MS, Park SH, Yoo BC, Kim KH, Jang YK [Cell Biochem Funct   35(5), 247-253(2017) ]


Cobll1; A New Player in CML

Hongtae Kim, Dong-Wook Kim, and Kyungjae Myung [Oncotarget   8(53), 90626-90627(2017) ]


SHPRH as a new player in ribosomal RNA transcription and its potential role in homeostasis of ribosomal DNA repeats

Deokjae Lee, Jun Hong Park, Shinseog Kim, Seon-gyeong Lee, and Kyungjae Myung [Transcription   (2017) ]


Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation

Jae Bin Lee, Mi Eun Kang, Joohee Kim, Chang Young Lee, Jung-Min Kee, Kyungjae Myung, Jang-Ung Park, and Sung You Hong [Chem. Comm. In Press   53(75), 10394-10397(2017) ]


An Annulative Synthetic Strategy for Building Triphenylene Frameworks by Multiple C-H Bond Activations.

Mathew BP, Yang HJ, Kim J, Lee JB, Kim YT, Lee S, Lee CY, Choe W, Myung K, Park JU, Hong SY. [Angew Chem Int Ed Engl.   56(18), 5007-5011(2017) ]


SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner

Deokjae Lee, Jungeun An, Young-Un Park, Hungjiun Liaw, Roger Woodgate, Jun Hong Park, and Kyungjae Myung [PNAS   114(17), 3424-3433(2017) ]


Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia

Han SH, Kim SH, Kim HJ, Lee Y, Choi SY, Park G, Kim DH, Lee A, Kim J, Choi JM, Kim Y, Myung K, Kim H, Kim DW. [Leukemia   (2017) ]



Copper-Catalyzed Direct Synthesis of 1,2,4-Oxadiazoles from Amides and Organic Nitriles by Oxidative N-O Bond Formation

Malleswara Rao Kuram, Woo Gyum Kim, Kyungjae Myung, and Sung You Hong [European Journal of Organic Chemistry   3, 438-442(2016) ]


PPARγ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue

Sun-Sil Choi, Eun-Sun Kim, Ji-Eun Jung, David P. Marciano, Ala Jo, Ja Young Koo, Soo Youn Choi, Young Ryoul Yang, Hyun-Jun Jang, Eung-Kyun Kim, Jiyoung Park, Hyug Moo Kwon, In Hee Lee, Seung Bum Park, Kyung-Jae Myung, Pann-Ghill Suh, Patrick R. Griffin and Jang Hyun Choi [Diabetes.   65(4), 829-839(2016) ]


C H bond arylation of anilides inside copper-exchanged zeolites

Bijoy P. Mathew, Hyun Ji Yang, Himchan Jeon, Jeong Hyeon Lee, Jin Chul Kim, Tae Joo Shin, Kyungjae Myung, Sang Kyu Kwak, Ja Hun Kwak, Sung You Hong [Journal of Molecular Catalysis A: Chemical   417, 64-70(2016) ]


A palladium and gold catalytic system enables direct access to O- and S-linked non-natural glyco-conjugates

Min Ho Jeon, Bijoy P. Mathew, Malleswara Rao Kuram, Kyungjae Myung, and Sung You Hong [Organic & Biomolecular Chemistry   14, 11518-11524(2016) ]


TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage.

Soo Lee N, Jin Chung H, Kim HJ, Yun Lee S, Ji JH, Seo Y, Hun Han S, Choi M, Yun M, Lee SG, Myung K, Kim Y, Chul Kang H, Kim H. [Nature Communications   7(10463)(2016) ]


A novel chemotherapeutic agent to treat tumors with DNA mismatch repair deficiencies

Yongliang Zhang, Jennifer T Fox, Young-Un Park, Gene Elliott, Ganesha Rai, Mengli Cai, Srilatha Sakamuru, Ruili Huang, Menghang Xia, Kyeryoung Lee, Min Ho Jeon, Bijoy p Mathew, Hee Dong Park, Winfried Edelmann, Chan Young Park, Sung You Hong, David Maloney, Kyungjae Myung [Cancer Research   76(14)(2016) ]



Acute loss of TET function results in aggressive myeloid cancer in mice

Jungeun An, Edahi Gonzalez-Avalos, Ashu Chawla, Mira Jeong, Issac F. Lopez-Moyado, Wei Li, Margaret A. Goodell, Lukas Chavez, Myunggon Ko and Anjana Rao [Nature communications   6(2015) ]


Targeting the cancer cell state

Kyungjae Myung [Cell Cycle 14(15), 2385-2386(2015) ]


Functions of TET Proteins in Hematopoietic Transformation

Jae-A Han, Jungeun An, and Myunggon Ko [Mol Cells.  38(11), 925-935(2015) ]


Anti-apoptotic effects of Silk fibroin hydrolysate in RIN5F cell on high glucose condition

Jun Hong Park, Kyung In Cho, Hajin Nam, Nong-Hoon Choe, Jun Gyo Suh [Animal Cells and Systems   19(3)(2015) ]


DNA methylation and hydroxymethylation in hematologic differentiation and transformation

Ko, M.;Jungeun An;Rao, A. [CURRENT OPINION IN CELL BIOLOGY   37, 91-101(2015) ]

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